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| カタログ番号 | MV984012 |
|---|---|
| 説明 |
Recombinant Mouse IL25/IL17E Protein, N-His (MV984012) expressed in E. coli, spanning Val17-Ala169. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q8VHH8 |
| タンパク質長 | Val17-Ala169 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 19.75 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | IL-17E, IL-25, IL17E, IL25, Interleukin-17E, Interleukin-25 |
| 背景 | Interleukin-25 is a ~19 kDa protein. Cytokine produced by various cells such as eosinophils, T-helper type 2 (Th2) cells or epithelial cells that plays a role in internal safety of adaptive immune responses by regulating cytokine production. Promotes and augments T-helper type 2 responses locally or systemically. Exerts its activity via its receptor composed of IL17RA and IL17RB for signal transduction. In turn, stimulates the JAK2-STAT5A pathway and promotes the secretion of type-2 associated cytokines including IL4, IL9 and IL13. Also induces the release of IL8, and IL6 from eosinophils through the combined activation of MAPK and NF-kappa-B pathways. 1. Fort, MM. et al. (2001) Immunity 15, 985-95. PMID: 11754819 2. Peng, B. et al. (2022) Frontiers in immunology 13, 842500. PMID: 35615348 3. Rickel, EA. et al. (2008) Journal of immunology (Baltimore, Md. : 1950) 181, 4299-310. PMID: 18768888 |
| 注意事項 | For research use only |
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