

| Каталожный номер | MB964012 |
|---|---|
| Описание |
Recombinant Mouse MDK/Midkine Protein, N-His (MB964012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| Система экспрессии | E. coli |
| Номер доступа | P12025 |
| Длина белка | Lys23-Asp140 |
| Применения | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Виды | Mus musculus (Mouse) |
| Характер | Recombinant |
| Уровень эндотоксинов | Please contact with the lab for this information. |
| Чистота | >90% as determined by SDS-PAGE. |
| Форма | Lyophilized |
| Буфер хранения | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
| Реконституция | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Доставка | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Альтернативные названия | MK, Mdk, Midkine, Mk, Retanoic acid-responsive protein, Retinoic acid-induced differentiation factor |
| Фон | Midkine is a ~15 kDa protein. Secreted protein that functions as a cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups. Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration. Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression. 1. Ichihara-Tanaka, K. et al. (2006) The Journal of biological chemistry 281, 30857-64. PMID: 16901907 2. Zou, P. et al. (2006) Journal of neurochemistry 99, 1470-9. PMID: 17230638 3. Horiba, M. et al. (2000) The Journal of clinical investigation 105, 489-95. PMID: 10683378 4. Ochiai, K. et al. (2004) Liver international : official journal of the International Association for the Study of the Liver 24, 484-91. PMID: 15482347 5. Kawai, H. et al. (2004) The American journal of pathology 165, 1603-12. PMID: 15509530 6. Horiba, M. et al. (2006) Circulation 114, 1713-20. PMID: 17015789 7. Takenaka, H. et al. (2009) American journal of physiology. Heart and circulatory physiology 296, H462-9. PMID: 19060126 8. Weckbach, LT. et al. (2014) Blood 123, 1887-96. PMID: 24458438 9. Haffner-Luntzer, M. et al. (2014) PloS one 9, e116282. PMID: 25551381 |
| Примечание | For research use only |

SDS-PAGE for Mouse MDK/Midkine Recombinant Protein (N-His)
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