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| カタログ番号 | MD465012 |
|---|---|
| 説明 |
Recombinant Mouse RIC8B Protein, N-His (MD465012) expressed in E. coli, spanning Met1-Ser291. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | Q80XE1 |
| タンパク質長 | Met1-Ser291 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 35.39 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Brain synembryn, Chaperone Ric-8B, RIC8B, Synembryn-B, hSyn |
| 背景 | Chaperone Ric-8B is a ~58 kDa protein. Chaperone that specifically binds and folds nascent G(s) G-alpha proteins (GNAS and GNAL) prior to G protein heterotrimer formation, promoting their association with the plasma membrane. Also acts as a guanine nucleotide exchange factor (GEF) for G(s) proteins by stimulating exchange of bound GDP for free GTP. Acts as an important component for odorant signal transduction by mediating GNAL (G(olf)-alpha) folding, thereby promoting-dependent cAMP accumulation in olfactory sensory neurons. 1. Gabay, M. et al. (2011) Science signaling 4, ra79. PMID: 22114146 2. Papasergi-Scott, MM. et al. (2023) Structure (London, England : 1993) 31, 553-564.e7. PMID: 36931277 3. Von Dannecker, LE. et al. (2005) The Journal of neuroscience : the official journal of the Society for Neuroscience 25, 3793-800. PMID: 15829631 4. Von Dannecker, LE. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 9310-4. PMID: 16754875 5. Chan, P. et al. (2011) The Journal of biological chemistry 286, 19932-42. PMID: 21467038 6. Machado, CF. et al. (2017) The Journal of neuroscience : the official journal of the Society for Neuroscience 37, 12202-12213. PMID: 29118104 |
| 注意事項 | For research use only |
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