

| Каталожный номер | MA790011 |
|---|---|
| Описание |
Recombinant Mouse TGFBR3 Protein, C-His (MA790011) expressed in Mammalian Cells, spanning Met1-Thr785. Purity: >90% by SDS-PAGE.
Highlights
|
| Система экспрессии | Mammalian cells |
| Номер доступа | O88393 |
| Длина белка | Met1-Thr785 |
| Применения | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| Виды | Mus musculus (Mouse) |
| Характер | Recombinant |
| Уровень эндотоксинов | Please contact with the lab for this information. |
| Чистота | >90% as determined by SDS-PAGE. |
| Прогнозируемая молекулярная масса | 88.18 kDa |
| Форма | Lyophilized |
| Буфер хранения | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
| Реконституция | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Доставка | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Альтернативные названия | Betaglycan, TGF-beta receptor type 3, TGF-beta receptor type III, TGFBR3, TGFR-3, Transforming growth factor beta receptor III, Transforming growth factor beta receptor type 3 |
| Фон | Transforming growth factor beta receptor type 3 is a ~93 kDa protein. Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5. Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B. 1. Li, Y. et al. (2018) Endocrinology 159, 4077-4091. PMID: 30364975 2. Brûlé, E. et al. (2021) Science advances 7, eabl4391. PMID: 34910520 |
| Примечание | For research use only |
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