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| カタログ番号 | MB024012 |
|---|---|
| 説明 |
Recombinant Mouse UCP1 Protein, N-GST & C-His (MB024012) expressed in E. coli. Purity: >90% as determined by SDS-PAGE..
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P12242 |
| タンパク質長 | Pro33-Lys73&Thr134-Thr178&Val233-Ala266 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Mus musculus (Mouse) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | Mitochondrial brown fat uncoupling protein 1, Slc25a7, Solute carrier family 25 member 7, Thermogenin, UCP 1, Ucp, Ucp1 |
| 背景 | Mitochondrial brown fat uncoupling protein 1 is a ~33 kDa protein. Mitochondrial transporter that functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Regulates the production of reactive oxygen species/ROS by mitochondria. 1. Fedorenko, A. et al. (2012) Cell 151, 400-13. PMID: 23063128 2. Feldmann, HM. et al. (2009) Cell metabolism 9, 203-9. PMID: 19187776 3. Chouchani, ET. et al. (2016) Nature 532, 112-6. PMID: 27027295 4. Enerbäck, S. et al. (1997) Nature 387, 90-4. PMID: 9139827 5. Dlasková, A. et al. (2010) Biochimica et biophysica acta 1797, 1470-6. PMID: 20416274 6. Oelkrug, R. et al. (2010) The Journal of biological chemistry 285, 21961-8. PMID: 20466728 |
| 注意事項 | For research use only |
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