ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Виды
Mus musculus (Mouse)
Характер
Recombinant
Уровень эндотоксинов
Please contact with the lab for this information.
Чистота
>90% as determined by SDS-PAGE.
Прогнозируемая молекулярная масса
20.85 kDa
Форма
Lyophilized
Буфер хранения
Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol.
Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Реконституция
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Доставка
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Устойчивость и хранение
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия
EC:3.1.-.-, Endoribonuclease ZC3H12A, MCP-induced protein 1, MCPIP, MCPIP-1, MCPIP1, Monocyte chemotactic protein-induced protein 1, Reg1, Regnase-1, ZC3H12A, Zinc finger CCCH domain-containing protein 12A
Фон
Endoribonuclease ZC3H12A is a ~65 kDa protein. Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angiogenesis. Functions as an endoribonuclease involved in mRNA decay. Modulates the inflammatory response by promoting the degradation of a set of translationally active cytokine-induced inflammation-related mRNAs, such as IL6 and IL12B, during the early phase of inflammation. Prevents aberrant T-cell-mediated immune reaction by degradation of multiple mRNAs controlling T-cell activation, such as those encoding cytokines (IL6 and IL2), cell surface receptors (ICOS, TNFRSF4 and TNFR2) and transcription factor (REL). Inhibits cooperatively with ZC3H12A the differentiation of helper T cells Th17 in lungs.
1. Mino, T. et al. (2015) Cell 161, 1058-1073. PMID: 26000482
2. Matsushita, K. et al. (2009) Nature 458, 1185-90. PMID: 19322177
3. Liang, J. et al. (2010) The Journal of experimental medicine 207, 2959-73. PMID: 21115689
4. Li, M. et al. (2012) PloS one 7, e49841. PMID: 23185455
5. Uehata, T. et al. (2013) Cell 153, 1036-49. PMID: 23706741
10. Huang, S. et al. (2015) The Journal of biological chemistry 290, 20782-20792. PMID: 26134560
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