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| カタログ番号 | RW587012 |
|---|---|
| 説明 |
Recombinant Rat GRIA1/GLUR1 Protein, N-His (RW587012) expressed in E. coli, spanning Asn23-Ala391. Purity: >90% by SDS-PAGE.
Highlights
|
| 発現システム | E. coli |
| アクセッション番号 | P19490 |
| タンパク質長 | Asn23-Ala391 |
| アプリケーション | ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress |
| 種 | Rattus norvegicus (Rat) |
| 性質 | Recombinant |
| エンドトキシンレベル | Please contact with the lab for this information. |
| 純度 | >90% as determined by SDS-PAGE. |
| 予測分子量 | 44.92 kDa |
| 形態 | Lyophilized |
| 保存バッファー | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 再構成 | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| 発送 | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | AMPA-selective glutamate receptor 1, GLUA1, GLUH1, GLUR1, GRIA1, GluR-1, GluR-A, GluR-K1, Glutamate receptor 1, Glutamate receptor ionotropic, AMPA 1 |
| 背景 | Glutamate receptor 1 is a ~101 kDa protein. Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG2 or CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate. 1. Keinänen, K. et al. (1990) Science (New York, N.Y.) 249, 556-60. PMID: 2166337 2. Boulter, J. et al. (1990) Science (New York, N.Y.) 249, 1033-7. PMID: 2168579 3. Jatzke, C. et al. (2002) The Journal of physiology 538, 25-39. PMID: 11773314 4. Kato, AS. et al. (2008) Neuron 59, 986-96. PMID: 18817736 5. Bedoukian, MA. et al. (2006) The Journal of biological chemistry 281, 23908-21. PMID: 16793768 6. Schwenk, J. et al. (2009) Science (New York, N.Y.) 323, 1313-9. PMID: 19265014 7. Hollmann, M. et al. (1991) Science (New York, N.Y.) 252, 851-3. PMID: 1709304 |
| 注意事項 | For research use only |
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