Research Grade Albiglutide (HW328306)

Name: Research Grade Albiglutide
Brand: abinScience
SKU: HW328306
Price: 352 USD
Availability: InStock

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Número de catálogo	HW328306
Descripción	Albiglutide (HW328306) is a research-grade recombinant antibody targeting GLP-1 receptor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Functional assay, Research in vivo
Especie huésped	Human
Isotipo	Fusion - (GCG (glucagon) 98-127 (glucagon-like peptide 1, GLP1) 7-36)2 - ALB (albumin, human serum albumin, HSA) 25-609
Sistema de expresión	Mammalian cells
Objetivo	GLP-1 receptor, Glucagon-like peptide 1 receptor, GLP1R, GLP-1-R, GLP-1R
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Purified by ion exchange chromatography.
Número de acceso	P43220
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	GSK716155, SyncriaEPERZAN®(EU), TANZEUM®(US)
Fondo	Glucagon-like peptide 1 receptor (GLP1R) is a ~53 kDa protein. G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. 1. Underwood, CR. et al. (2010) The Journal of biological chemistry 285, 723-30. PMID: 19861722 2. Lau, J. et al. (2015) Journal of medicinal chemistry 58, 7370-80. PMID: 26308095 3. Hennen, S. et al. (2016) Scientific reports 6, 26236. PMID: 27196125 4. Song, G. et al. (2017) Nature 546, 312-315. PMID: 28514449 5. van Eyll, B. et al. (1994) FEBS letters 348, 7-13. PMID: 7517895 6. Graziano, MP. et al. (1993) Biochemical and biophysical research communications 196, 141-6. PMID: 8216285 7. Thorens, B. et al. (1993) Diabetes 42, 1678-82. PMID: 8405712
Nota	For research use only. Not suitable for clinical or therapeutic use.