Research Grade Alteplase (HF934026)

Name: Research Grade Alteplase
Brand: abinScience
SKU: HF934026
Price: 424 USD
Availability: InStock

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Número de catálogo	HF934026
Descripción	Research Grade Alteplase (HF934026) is a monoclonal antibody detecting t-Plasminogen Activator/tPA. Expressed in Mammalian cells.
Reactividad de especies	Human
Aplicaciones	ELISA, Functional assay, Research in vivo
Clonalidad	Monoclonal
Isotipo	Recombinant tissue plasminogen activator (rt-PA) with C-terminal 6*His
Actividad biológica	Alteplase (8.3 and 250 ug/mL, 12 h) shows a signifcant reduction in viability of human fetal retinal pigment epithelial (hfRPE cells) [4]. Alteplase (8.3 and 250 ug/mL, 0-6 h) signifcantly decreases the transepithelial resistance in a time-dependent manner and induces cell death in hfRPE cells [4]. Alteplase (0.9-10 mg/kg, i.v.
Sistema de expresión	Mammalian cells
Naturaleza	Recombinant
Objetivo	Tissue-type plasminogen activator, t-PA, t-plasminogen activator, tPA, 3.4.21.68, Alteplase, Reteplase, Tissue-type plasminogen activator chain A, Tissue-type plasminogen activator chain B, PLAT
Nivel de endotoxinas	< 10 EU/mg as determined by LAL method.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Purified by Nickel column.
Número de acceso	P00750
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	105857-23-6
Fondo	Tissue-type plasminogen activator (PLAT/tPA) is a ~62 kDa protein. Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy. _x005F_x000D_
Referencias	1. J Bastecký, et al. [Actilyse (a recombinant tissue-type plasminogen activator] in the treatment of acute myocardial infarct. Comparison of the effects of Actilyse and streptokinase]. Vnitr Lek. 1994 May;40(5):293-8. [HF934026] 2. Micieli G, et al. Safety and efficacy of alteplase in the treatment of acute ischemic stroke. Vasc Health Risk Manag. 2009;5(1):397-409. [HF934026] 3. Orset C, et al. Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis. Stroke. 2016 May;47(5):1312-1318. [HF934026] 4. Kimura S, et al. Cytotoxic effects of alteplase, a recombinant tissue plasminogen activator, on human retinal pigment epithelial cells. Jpn J Ophthalmol. 2021 Sep;65(5):731-739. View More [HF934026]
Nota	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Alteplase

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Research Grade Alteplase.pdf

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Research Grade Alteplase (HF934026)

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Datasheet

SDS