

| Número de catálogo | HW688026 | ||||
|---|---|---|---|---|---|
| Descripción |
Research Grade Anti-FLT3 ligand Antibody (AMG 329) [AMG 329] (HW688026) is a human monoclonal antibody detecting Receptor-type tyrosine-protein kinase FLT3 in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human.
Highlights
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| Reactividad de especies | Human | ||||
| Aplicaciones | ELISA, Bioactivity: FCM, Functional assay, Research in vivo | ||||
| Especie huésped | Human | ||||
| Clonalidad | Monoclonal | ||||
| Isotipo | IgG1, lambda | ||||
| ID de clon | AMG 329 | ||||
| Sistema de expresión | Mammalian cells | ||||
| Naturaleza | Recombinant | ||||
| Objetivo | Receptor-type tyrosine-protein kinase FLT3, EC:2.7.10.1, FL cytokine receptor, Fetal liver kinase-2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Stem cell tyrosine kinase 1, STK-1, CD135, FLT3, CD135, FLK2, STK1 | ||||
| Nivel de endotoxinas | < 10 EU/mg as determined by LAL method. | ||||
| Pureza | >95% as determined by SDS-PAGE. | ||||
| Purificación | Protein A/G purified from cell culture supernatant. | ||||
| Número de acceso | P36888 | ||||
| Forma | Liquid | ||||
| Buffer de almacenamiento | 0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote. |
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| Información de uso del producto |
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| Estabilidad y almacenamiento | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| Nombres alternativos | MEDI1116,VIB-1116, HZN-1116, VIB 1116, VIB1116, HZN 1116, HZN1116 | ||||
| Fondo | Receptor-type tyrosine-protein kinase FLT3 (FLT3 ligand) is a ~112 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. | ||||
| Nota | For research use only. Not suitable for clinical or therapeutic use. |

SDS-PAGE for Research Grade Anti-FLT3 ligand Antibody (AMG 329)




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