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| カタログ番号 | HW688026 | ||||
|---|---|---|---|---|---|
| 説明 |
Research Grade Anti-FLT3 ligand Antibody (AMG 329) [AMG 329] (HW688026) is a human monoclonal antibody detecting Receptor-type tyrosine-protein kinase FLT3 in ELISA, Bioactivity: FACS, Functional assay, Research in vivo. Suitable for Human.
Highlights
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| 種反応性 | Human | ||||
| アプリケーション | ELISA, Bioactivity: FCM, Functional assay, Research in vivo | ||||
| 宿主種 | Human | ||||
| クローン性 | Monoclonal | ||||
| アイソタイプ | IgG1, lambda | ||||
| クローンID | AMG 329 | ||||
| 発現システム | Mammalian cells | ||||
| 性質 | Recombinant | ||||
| ターゲット | Receptor-type tyrosine-protein kinase FLT3, EC:2.7.10.1, FL cytokine receptor, Fetal liver kinase-2, FLK-2, Fms-like tyrosine kinase 3, FLT-3, Stem cell tyrosine kinase 1, STK-1, CD135, FLT3, CD135, FLK2, STK1 | ||||
| エンドトキシンレベル | < 10 EU/mg as determined by LAL method. | ||||
| 純度 | >95% as determined by SDS-PAGE. | ||||
| 精製 | Protein A/G purified from cell culture supernatant. | ||||
| アクセッション番号 | P36888 | ||||
| 形態 | Liquid | ||||
| 保存バッファー | 0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
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| 製品使用情報 |
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| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. | ||||
| 別名 | MEDI1116,VIB-1116, HZN-1116, VIB 1116, VIB1116, HZN 1116, HZN1116 | ||||
| 背景 | Receptor-type tyrosine-protein kinase FLT3 (FLT3 ligand) is a ~112 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. | ||||
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
SDS-PAGE for Research Grade Anti-FLT3 ligand Antibody (AMG 329)
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