Anti-HIV-1 gp120 Reference Antibody (mD1.22, RUO) (VK617106)

Name: Anti-HIV-1 gp120 Reference Antibody (mD1.22, RUO)
Brand: abinScience
SKU: VK617106
Price: 370 USD
Availability: InStock

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Aperçu

Numéro de catalogue

VK617106

Description

Anti-HIV1 gp120/Glycoprotein 120 Antibody (mD1.22) (VK617106) is a research-grade recombinant antibody targeting CD4. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

Reactivité des espèces

Human immunodeficiency virus type 1 (HIV-1)

Applications

ELISA, Functional assay, Research in vivo

Espèce hôte

Human

Clonalité

Monoclonal

Isotype

Fusion - [CD4 (LFA3, lymphocyte function associated antigen 3)]2 - IGHG1 Fc (Fragment constant)

ID de clone

mD1.22

Système d'expression

Mammalian cells

Cible

T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4, CD4

Niveau d'endotoxines

< 10 EU/mg

Pureté

>95% purity as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P01730

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Contexte

T-cell surface glycoprotein CD4 (gp120/Glycoprotein 120) is a ~51 kDa protein. Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex.

Note

For research use only. Not suitable for clinical or therapeutic use.

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