Anti-Human Activin Receptor IIB Reference Antibody (KER-012, RUO) (HC570026)

Name: Anti-Human Activin Receptor IIB Reference Antibody (KER-012, RUO)
Brand: abinScience
SKU: HC570026
Price: 370 USD
Availability: InStock

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Numéro de catalogue	HC570026
Description	Anti-Human ACVR2B Antibody (KER-012) (HC570026) is a research-grade recombinant antibody targeting ACTR-IIB. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Functional assay, Research in vivo
Clonalité	Monoclonal
Isotype	Fusion-[human ACTR-IIB]2-Fc (Fragment constant)
ID de clone	KER-012
Système d'expression	Mammalian cells
Cible	ACTR-IIB, Activin receptor type IIB, Activin receptor type-2B, ACVR2B
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q13705
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	KER012, RKER-012, RKER012
Contexte	Activin receptor type-2B (ACVR2B) is a ~57 kDa protein. Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals.
Note	For research use only. Not suitable for clinical or therapeutic use.