Anti-Human Activin Receptor IIB Reference Antibody (KER-012, RUO) (HC570026)

Name: Anti-Human Activin Receptor IIB Reference Antibody (KER-012, RUO)
Brand: abinScience
SKU: HC570026
Price: 370 USD
Availability: InStock

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概要

カタログ番号	HC570026
説明	Anti-Human ACVR2B Antibody (KER-012) (HC570026) is a research-grade recombinant antibody targeting ACTR-IIB. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Functional assay, Research in vivo
クローン性	Monoclonal
アイソタイプ	Fusion-[human ACTR-IIB]2-Fc (Fragment constant)
クローンID	KER-012
発現システム	Mammalian cells
ターゲット	ACTR-IIB, Activin receptor type IIB, Activin receptor type-2B, ACVR2B
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	Q13705
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	KER012, RKER-012, RKER012
背景	Activin receptor type-2B (ACVR2B) is a ~57 kDa protein. Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals.
注意事項	For research use only. Not suitable for clinical or therapeutic use.