Anti-Human Activin Receptor IIB Reference Antibody (KER-012, RUO) (HC570026)

Name: Anti-Human Activin Receptor IIB Reference Antibody (KER-012, RUO)
Brand: abinScience
SKU: HC570026
Price: 370 USD
Availability: InStock

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Каталожный номер	HC570026
Описание	Anti-Human ACVR2B Antibody (KER-012) (HC570026) is a research-grade recombinant antibody targeting ACTR-IIB. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Functional assay, Research in vivo
Клоональность	Monoclonal
Изотип	Fusion-[human ACTR-IIB]2-Fc (Fragment constant)
ID клона	KER-012
Система экспрессии	Mammalian cells
Цель	ACTR-IIB, Activin receptor type IIB, Activin receptor type-2B, ACVR2B
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	Q13705
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	KER012, RKER-012, RKER012
Фон	Activin receptor type-2B (ACVR2B) is a ~57 kDa protein. Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals.
Примечание	For research use only. Not suitable for clinical or therapeutic use.