Anti-Human Axl Reference Antibody (ORY012, RUO) (HB709066)

Name: Anti-Human Axl Reference Antibody (ORY012, RUO)
Brand: abinScience
SKU: HB709066
Price: 370 USD
Availability: InStock

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Número de catálogo	HB709066
Descripción	Anti-Human AXL/UFO (ORY012) (HB709066) is a research-grade recombinant antibody targeting UFO. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	ORY012
Sistema de expresión	Mammalian cells
Naturaleza	Recombinant
Objetivo	UFO, AXL oncogene, Tyrosine-protein kinase receptor UFO, AXL
Nivel de endotoxinas	< 10 EU/mg as determined by LAL method.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P30530
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	ORY012
Fondo	Tyrosine-protein kinase receptor UFO (AXL) is a ~98 kDa protein. Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase.
Nota	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human AXL/UFO (ORY012)

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Datasheet

Anti-Human Axl Reference Antibody (ORY012, RUO).pdf

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Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Anti-Human Axl Reference Antibody (ORY012, RUO) (HB709066)

Vista general

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Referencias

Datasheet

SDS