Anti-Human IL-4R alpha Reference Antibody (12B5, RUO) (HB732046)

Name: Anti-Human IL-4R alpha Reference Antibody (12B5, RUO)
Brand: abinScience
SKU: HB732046
Price: 370 USD
Availability: InStock

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Каталожный номер	HB732046
Описание	Anti-Human CD124/IL4R/IL-4Rα Antibody (12B5) (HB732046) is a research-grade recombinant antibody targeting CD124. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG1
ID клона	12B5
Цель	CD124, IL-4 receptor subunit alpha, IL-4-binding protein, IL-4R subunit alpha, IL-4R-alpha, IL-4RA, IL4-BP, IL4R, IL4RA, Interleukin-4 receptor subunit alpha, Soluble IL-4 receptor subunit alpha, Soluble IL-4R-alpha, Soluble interleukin-4 receptor subunit alpha, sIL4Ralpha/prot
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P24394
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Фон	Interleukin-4 receptor subunit alpha (CD124/IL4R) is a ~89 kDa protein. Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. CD124 is the therapeutic target of dupilumab (Dupixent). 1. Andrews, AL. et al. (2006) The Journal of allergy and clinical immunology 118, 858-65. PMID: 17030238
Примечание	For research use only. Not suitable for clinical or therapeutic use.