Anti-Human SIRP alpha/CD172a Reference Antibody (ES004, RUO) (HX892076)

Name: Anti-Human SIRP alpha/CD172a Reference Antibody (ES004, RUO)
Brand: abinScience
SKU: HX892076
Price: 326 USD
Availability: InStock

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Каталожный номер	HX892076
Описание	Anti-Human SIRP alpha/CD172a Reference Antibody (ES004, RUO) (HX892076) is a human monoclonal antibody detecting SIRP alpha/CD172a.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG
ID клона	ES004
Система экспрессии	Mammalian cells
Характер	Recombinant
Цель	BIT, Bit, Brain Ig-like molecule with tyrosine-based activation motifs, CD172 antigen-like family member A, CD172a, Inhibitory receptor SHPS-1, MFR, MYD1, Macrophage fusion receptor, MyD-1 antigen, PTPNS1, SHP substrate 1, SHPS-1, SHPS1, SIRP, SIRPA, Signal-regulatory protein alpha-1, Signal-regulatory protein alpha-2, Signal-regulatory protein alpha-3, Sirp-alpha-1, Sirp-alpha-2, Sirp-alpha-3, Tyrosine-protein phosphatase non-receptor type substrate 1, p84
Уровень эндотоксинов	< 10 EU/mg as determined by LAL method.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P78324
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	ES004
Фон	Tyrosine-protein phosphatase non-receptor type substrate 1 (CD172a/SIRPA) is a ~54 kDa protein. Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. 1. Yao, M. et al. (2014) Journal of the American Society of Nephrology : JASN 25, 1171-86. PMID: 24511121
Ссылки	1. Niu X, et al. A pan-allelic human SIRPα-blocking antibody, ES004-B5, promotes tumor killing by enhancing macrophage phagocytosis and subsequently inducing an effective T-cell response. Antib Ther. 2024 Aug 28;7(3):266-280. [HX892076]
Примечание	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human CD172a/SIRPA (ES004)

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Anti-Human SIRP alpha/CD172a Reference Antibody (ES004, RUO).pdf

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Anti-Human SIRP alpha/CD172a Reference Antibody (ES004, RUO) (HX892076)

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