Anti-Human CCR8 Reference Antibody (HFB101110, RUO) (HW444046)

Name: Anti-Human CCR8 Reference Antibody (HFB101110, RUO)
Brand: abinScience
SKU: HW444046
Price: 370 USD
Availability: InStock

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Número de catálogo	HW444046
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	HFB101110
Actividad biológica	HFB101110 (0.01-10 nM) dose-dependently inhibits hCCL1-induced chemotaxis of CCR8 + cells [1]. HFB101110 (10 ug/mL) completely inhibits hCCL1-induced calcium flux in CCR8 + cells [1]. HFB101110 (0.3-300 ug/mL) does not induce significant cytokine release from healthy human PBMCs at concentrations up to 300 ug/mL [1]. HFB101110 exerts potent single-agent antitumor activity in a human CCR8 knock-in mouse model via depletion of intratumoral regulatory T cells [2]. HFB101110 is well-tolerated in wild-type mice [2]. HFB101110 is well-tolerated in cynomolgus monkeys [2].
Sistema de expresión	Mammalian cells
Objetivo	CKR-L1, CMKBR8, C-C CKR-8, GPR-CY6, CCR8, CMKBRL2, TER1, CCR-8, Chemokine receptor-like 1, CKRL1, CDw198, GPRCY6, C-C chemokine receptor type 8, CC-CKR-8, CC chemokine receptor CHEMR1
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P51685
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	HFB101110
Fondo	C-C chemokine receptor type 8 (CD198/CCR8) is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage. 1. Islam, SA. et al. (2013) The Journal of experimental medicine 210, 1889-98. PMID: 23999500 2. Ding, D. et al. (2022) Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 42, 19-28. PMID: 35041514
Referencias	1. PRIGENT J, et al. Anti-ccr8 antibodies and uses thereof: U.S. Patent Application 18/685,068[P]. 2025-1-16. [HW444046] 2. Kumar R M, et al. Targeting regulatory T cells with HFB101110, a novel anti-human CCR8 antibody for the treatment of solid tumors[J]. Cancer Research, 2022, 82(12_Supplement): 2899-2899. [HW444046]
Nota	For research use only. Not suitable for clinical or therapeutic use.