Anti-Human CCR8 Reference Antibody (HFB101110, RUO) (HW444046)

Name: Anti-Human CCR8 Reference Antibody (HFB101110, RUO)
Brand: abinScience
SKU: HW444046
Price: 370 USD
Availability: InStock

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100ug
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概要
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参考文献
データシート
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概要

カタログ番号	HW444046
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG
クローンID	HFB101110
生物学的活性	HFB101110 (0.01-10 nM) dose-dependently inhibits hCCL1-induced chemotaxis of CCR8 + cells [1]. HFB101110 (10 ug/mL) completely inhibits hCCL1-induced calcium flux in CCR8 + cells [1]. HFB101110 (0.3-300 ug/mL) does not induce significant cytokine release from healthy human PBMCs at concentrations up to 300 ug/mL [1]. HFB101110 exerts potent single-agent antitumor activity in a human CCR8 knock-in mouse model via depletion of intratumoral regulatory T cells [2]. HFB101110 is well-tolerated in wild-type mice [2]. HFB101110 is well-tolerated in cynomolgus monkeys [2].
発現システム	Mammalian cells
ターゲット	CKR-L1, CMKBR8, C-C CKR-8, GPR-CY6, CCR8, CMKBRL2, TER1, CCR-8, Chemokine receptor-like 1, CKRL1, CDw198, GPRCY6, C-C chemokine receptor type 8, CC-CKR-8, CC chemokine receptor CHEMR1
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P51685
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	HFB101110
背景	C-C chemokine receptor type 8 (CD198/CCR8) is a ~40 kDa protein. G protein-coupled receptor that can bind a variety of chemokines, such as CCL1, CCL8, CCL16, CCL18. Regulates monocyte and eosinophil chemotaxis. Undergoes internalization upon CCL18 binding, leading to induced migration and calcium flux of highly polarized Th2 cells. In microglial cells, promotes phagocytosis with CCL18 through NF-kappa-B and Src signaling pathways. Stimulation of the CCL1-CCR8 signaling axis protects the gut from acute intestinal damage. 1. Islam, SA. et al. (2013) The Journal of experimental medicine 210, 1889-98. PMID: 23999500 2. Ding, D. et al. (2022) Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 42, 19-28. PMID: 35041514
参考文献	1. PRIGENT J, et al. Anti-ccr8 antibodies and uses thereof: U.S. Patent Application 18/685,068[P]. 2025-1-16. [HW444046] 2. Kumar R M, et al. Targeting regulatory T cells with HFB101110, a novel anti-human CCR8 antibody for the treatment of solid tumors[J]. Cancer Research, 2022, 82(12_Supplement): 2899-2899. [HW444046]
注意事項	For research use only. Not suitable for clinical or therapeutic use.