Anti-Human MUC-1 Reference Antibody (TAB-004, RUO) (HB102186)

Name: Anti-Human MUC-1 Reference Antibody (TAB-004, RUO)
Brand: abinScience
SKU: HB102186
Price: 176 USD
Availability: InStock

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概要
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概要

カタログ番号	HB102186
種反応性	Human
アプリケーション	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG
クローンID	TAB-004
生物学的活性	TAB-004 (30 min) specifically binds to human tMUC1-expressing MMT murine breast cancer cells, with no detectable binding to tMUC1-negative PyMT murine breast cancer cells [1]. TAB-004 (3 ng/ml) potently and specifically binds to the MUC1 peptide with detectable binding at 20 pM in a cell-free ELISA [2]. TAB-004 specifically detects human MUC1 in human and murine pancreatic cancer cell lines (KCM, BxPC3.MUC1, HPAF-II) via Western blot, with no cross-reactivity to murine MUC1 in KCKO cells [2]. TAB-004 specifically detects the expression of tMUC1 in BxPC3, PANC-1 and HPAF-II human pancreatic cancer cells by flow cytometry, and can recognize tMUC1 on the surface of more than 95% of Triple + and CD133 + pancreatic cancer stem cells [2]. targeted imaging. TAB-004 can be used for the research of early detection, tumor progression monitoring and cancer stem cell targeting in breast cancer and pancreatic cancer. [1] [2]
ターゲット	Breast carcinoma-associated antigen DF3, CA 15-3, CD227, Cancer antigen 15-3, Carcinoma-associated mucin, EMA, Episialin, H23AG, KL-6, Krebs von den Lungen-6, MUC-1, MUC1, MUC1-CT, MUC1-NT, MUC1-alpha, MUC1-beta, Mucin-1, Mucin-1 subunit alpha, Mucin-1 subunit beta, PEM, PEMT, PUM, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin
エンドトキシンレベル	< 10 EU/mg
純度	>95% as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P15941
形態	Liquid
保存バッファー	0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	TAB-004, TAB004, TAB004
背景	Mucin-1 (CD227/MUC1) is a ~122 kDa protein. The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack.
参考文献	1. Moore LJ, et al. Antibody-Guided In Vivo Imaging for Early Detection of Mammary Gland Tumors. Transl Oncol. 2016 Aug;9(4):295-305. [HB102186] 2. Curry JM, et al. The use of a novel MUC1 antibody to identify cancer stem cells and circulating MUC1 in mice and patients with pancreatic cancer. J Surg Oncol. 2013;107(7):713-722. [HB102186]
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)