Anti-Human TRANCE/TNFSF11/RANK L Reference Antibody (ONS-4010, RUO) (HT439086)

Name: Anti-Human TRANCE/TNFSF11/RANK L Reference Antibody (ONS-4010, RUO)
Brand: abinScience
SKU: HT439086
Price: 326 USD
Availability: InStock

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Número de catálogo	HT439086
Descripción	Anti-Human CD254/RANKL/TNFSF11 (ONS-4010) (HT439086) is a research-grade recombinant antibody targeting CD254. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	ONS-4010
Sistema de expresión	Mammalian cells
Naturaleza	Recombinant
Objetivo	ODF, TNF-related activation-induced cytokine, Osteoclast differentiation factor, TNFSF11, TRANCE, Osteoprotegerin ligand, RANKL, Tumor necrosis factor ligand superfamily member 11, Receptor activator of nuclear factor kappa-B ligand, CD254, OPGL
Nivel de endotoxinas	< 10 EU/mg as determined by LAL method.
Pureza	>95% as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	O14788
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4. Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	ONS-4010, ONS4010, ONS4010
Fondo	Tumor necrosis factor ligand superfamily member 11 (CD254/RANKL) is a ~35 kDa protein. Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. CD254 is the therapeutic target of denosumab (Prolia). 1. Luan, X. et al. (2012) Journal of immunology (Baltimore, Md. : 1950) 189, 245-52. PMID: 22664871
Nota	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD254/RANKL/TNFSF11 (ONS-4010)

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Datasheet

Anti-Human TRANCE/TNFSF11/RANK L Reference Antibody (ONS-4010, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Anti-Human TRANCE/TNFSF11/RANK L Reference Antibody (ONS-4010, RUO) (HT439086)

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Referencias

Datasheet

SDS