Anti-Human LAIR1 Reference Antibody (IO 106, RUO) (HV765026)

Name: Anti-Human LAIR1 Reference Antibody (IO 106, RUO)
Brand: abinScience
SKU: HV765026
Price: 176 USD
Availability: InStock

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SDS

Vista general

Número de catálogo	HV765026
Descripción	Anti-Human CD305/LAIR1 (IO 106) (HV765026) is a research-grade recombinant antibody targeting CD305. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1-kappa
ID de clon	IO 106
Sistema de expresión	Mammalian cells
Objetivo	Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, LAIR1, CD305
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q6GTX8
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	IO-106, IO106, IO106
Fondo	Leukocyte-associated immunoglobulin-like receptor 1 (CD305/LAIR1) is a ~31 kDa protein. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta.
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 (LALAPG) Recombinant Isotype Control Antibody (HyHEL-10) (HP688307) Human IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107)

Imágenes

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD305/LAIR1 (IO 106).
Western blot

Western blot analysis was performed using anti-CD305/LAIR1 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD305/LAIR1 (Catalog No: HV765011)
Lane 2: negative control
Bioactivity

Detects recombinant CD305 (Catalog No: HV765011) in indirect ELISA.