Anti-Human LAIR1 Reference Antibody (IO 106, RUO) (HV765026)

Name: Anti-Human LAIR1 Reference Antibody (IO 106, RUO)
Brand: abinScience
SKU: HV765026
Price: 176 USD
Availability: InStock

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Aperçu

Numéro de catalogue	HV765026
Description	Anti-Human CD305/LAIR1 (IO 106) (HV765026) is a research-grade recombinant antibody targeting CD305. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1-kappa
ID de clone	IO 106
Système d'expression	Mammalian cells
Cible	Leukocyte-associated immunoglobulin-like receptor 1, LAIR-1, hLAIR1, LAIR1, CD305
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q6GTX8
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	IO-106, IO106, IO106
Contexte	Leukocyte-associated immunoglobulin-like receptor 1 (CD305/LAIR1) is a ~31 kDa protein. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta.
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 (LALAPG) Recombinant Isotype Control Antibody (HyHEL-10) (HP688307) Human IgG1 (LALA) Recombinant Isotype Control Antibody (HyHEL-10) (HP688107)

Images

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD305/LAIR1 (IO 106).
Western blot

Western blot analysis was performed using anti-CD305/LAIR1 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human CD305/LAIR1 (Catalog No: HV765011)
Lane 2: negative control
Bioactivity

Detects recombinant CD305 (Catalog No: HV765011) in indirect ELISA.