Anti-Human VEGFR2/KDR/Flk-1 Reference Antibody (IMC-1C11, RUO) (HW338013)

Name: Anti-Human VEGFR2/KDR/Flk-1 Reference Antibody (IMC-1C11, RUO)
Brand: abinScience
SKU: HW338013
Price: 176 USD
Availability: InStock

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100ug
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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号

HW338013

説明

Anti-Human CD309/KDR/VEGFR-2 (IMC-1C11) (HW338013) is a research-grade recombinant antibody targeting CD309. Produced in mammalian cells with native-like glycosylation.

Highlights

●Research Grade — For PK/PD studies, assay development, and ADA research.
●Native Glycosylation — Mammalian expression ensures native-like patterns.

種反応性

Human

アプリケーション

ELISA, Bioactivity: FCM, Functional assay, Research in vivo

宿主種

Chimeric

クローン性

Monoclonal

アイソタイプ

IgG1

クローンID

IMC-1C11

ターゲット

CD309, EC:2.7.10.1, FLK-1, FLK1, Fetal liver kinase 1, KDR, Kinase insert domain receptor, Protein-tyrosine kinase receptor flk-1, VEGFR-2, VEGFR2, Vascular endothelial growth factor receptor 2

エンドトキシンレベル

< 10 EU/mg

純度

>95% as determined by SDS-PAGE.

精製

Protein A/G purified from cell culture supernatant.

アクセッション番号

P35968

形態

Liquid

保存バッファー

0.01M PBS pH 7.4.

データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。

製品使用情報

アプリケーション	希釈
ELISA	1:2000-1:20000

安定性と保存

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

背景

Vascular endothelial growth factor receptor 2 (CD309/VEGFR-2) is a ~151 kDa protein. Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFC and VEGFD. Plays an essential role in the regulation of angiogenesis, vascular development, vascular permeability, and embryonic hematopoiesis. Promotes proliferation, survival, migration and differentiation of endothelial cells. Promotes reorganization of the actin cytoskeleton. Isoforms lacking a transmembrane domain, such as isoform 2 and isoform 3, may function as decoy receptors for VEGFA, VEGFC and/or VEGFD. CD309 is the therapeutic target of ramucirumab (Cyramza).

注意事項

For research use only. Not suitable for clinical or therapeutic use.

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