Anti-Human CRACC/SLAMF7 Reference Antibody (BSI-046, RUO) (HV217036)

Name: Anti-Human CRACC/SLAMF7 Reference Antibody (BSI-046, RUO)
Brand: abinScience
SKU: HV217036
Price: 326 USD
Availability: InStock

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Numéro de catalogue	HV217036
Description	Anti-Human CD319/SLAMF7 (BSI-046) (HV217036) is a research-grade recombinant antibody targeting CD2. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG
ID de clone	BSI-046
Système d'expression	Mammalian cells
Cible	SLAMF7, CRACC, Protein 19A, SLAM family member 7, CD2-like receptor-activating cytotoxic cells, Membrane protein FOAP-12, CD319, Novel Ly9, CD2 subset 1, CS1
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q9NQ25
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	BSI-046, BSI046, BSI046
Contexte	SLAM family member 7 (CD319/SLAMF7) is a ~37 kDa protein. Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. 1. Bouchon, A. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 5517-21. PMID: 11698418 2. Tassi, I. et al. (2005) Journal of immunology (Baltimore, Md. : 1950) 175, 7996-8002. PMID: 16339536 3. Murphy, JJ. et al. (2002) The Biochemical journal 361, 431-6. PMID: 11802771 4. Kim, JR. et al. (2013) Inflammation research : official journal of the European Histamine Research Society ... [et al.] 62, 765-72. PMID: 23695528
Note	For research use only. Not suitable for clinical or therapeutic use.