Anti-Human EpCAM/TROP1 Reference Antibody (HPN601, RUO) (HB104126)

Name: Anti-Human EpCAM/TROP1 Reference Antibody (HPN601, RUO)
Brand: abinScience
SKU: HB104126
Price: 370 USD
Availability: InStock

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概要
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データシート
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概要

カタログ番号	HB104126
種反応性	Human
アプリケーション	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG
クローンID	HPN601
生物学的活性	HPN601 shows durable tumor regression in a humanized rodent tumor model and can be safely administered at doses tenfold higher than the minimal efficacious dose, while higher doses produce toxicities including elevated ALT/AST, bilirubin, body weight loss, and histopathological evidence of tissue damage [1]. HPN601 demonstrates a tenfold improved therapeutic window compared to a constitutively active EpCAM-targeting T cell engager and significantly attenuates cytokine production including IFN-γ, IL-2, IL-6, and IL-10 in non-human primates [1].
ターゲット	Adenocarcinoma-associated antigen, CD326, Cell surface glycoprotein Trop-1, EGP, EGP314, EPCAM, Ep-CAM, Epithelial cell adhesion molecule, Epithelial cell surface antigen, Epithelial glycoprotein, Epithelial glycoprotein 314, GA733-2, KS 1/4 antigen, KSA, M1S2, M4S1, MIC18, Major gastrointestinal tumor-associated protein GA733-2, TACSTD1, TROP1, Tumor-associated calcium signal transducer 1, hEGP314
エンドトキシンレベル	< 10 EU/mg
純度	>95% as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P16422
形態	Liquid
保存バッファー	0.01M PBS pH 7.4. データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	HPN601
背景	Epithelial cell adhesion molecule (CD326/EPCAM) is a ~34 kDa protein. May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
参考文献	1. Lin J, et al. 632 HPN601 is a protease-activated EpCAM-targeting T cell engager with an improved safety profile for the treatment of solid tumors. Journal for ImmunoTherapy of Cancer. 2020;8. [HB104126]
注意事項	For research use only. Not suitable for clinical or therapeutic use.