Anti-Human EpCAM/TROP1 Reference Antibody (HPN601, RUO) (HB104126)

Name: Anti-Human EpCAM/TROP1 Reference Antibody (HPN601, RUO)
Brand: abinScience
SKU: HB104126
Price: 370 USD
Availability: InStock

Даташит Поделиться продуктом Копировать информацию

Цена(USD):

Спецификация:

100ug
1mg
5mg
10mg
25mg
50mg
100mg

Количество:

Свяжитесь с нами

Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер	HB104126
Реактивность видов	Human
Применения	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG
ID клона	HPN601
Биологическая активность	HPN601 shows durable tumor regression in a humanized rodent tumor model and can be safely administered at doses tenfold higher than the minimal efficacious dose, while higher doses produce toxicities including elevated ALT/AST, bilirubin, body weight loss, and histopathological evidence of tissue damage [1]. HPN601 demonstrates a tenfold improved therapeutic window compared to a constitutively active EpCAM-targeting T cell engager and significantly attenuates cytokine production including IFN-γ, IL-2, IL-6, and IL-10 in non-human primates [1].
Цель	Adenocarcinoma-associated antigen, CD326, Cell surface glycoprotein Trop-1, EGP, EGP314, EPCAM, Ep-CAM, Epithelial cell adhesion molecule, Epithelial cell surface antigen, Epithelial glycoprotein, Epithelial glycoprotein 314, GA733-2, KS 1/4 antigen, KSA, M1S2, M4S1, MIC18, Major gastrointestinal tumor-associated protein GA733-2, TACSTD1, TROP1, Tumor-associated calcium signal transducer 1, hEGP314
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P16422
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	HPN601
Фон	Epithelial cell adhesion molecule (CD326/EPCAM) is a ~34 kDa protein. May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
Ссылки	1. Lin J, et al. 632 HPN601 is a protease-activated EpCAM-targeting T cell engager with an improved safety profile for the treatment of solid tumors. Journal for ImmunoTherapy of Cancer. 2020;8. [HB104126]
Примечание	For research use only. Not suitable for clinical or therapeutic use.