Anti-Human Fc gamma RIIB/CD32b Reference Antibody (SM201, RUO) (HB103066)

Name: Anti-Human Fc gamma RIIB/CD32b Reference Antibody (SM201, RUO)
Brand: abinScience
SKU: HB103066
Price: 176 USD
Availability: InStock

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100ug
1mg
5mg
10mg
25mg
50mg
100mg

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Referencias
Datasheet
SDS

Vista general

Número de catálogo	HB103066
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1
ID de clon	SM201
Actividad biológica	SM201 (5 ug/mL) specifically binds to Fc-RIIB on Raji cells and shows no cross-reactivity with Fc-RIIA on K-562 cells [1]. SM201 (0.01-10 ug/mL; 1 h) does not interfere with the binding of IgG to Fc-RIIB on Raji cells [1].
Sistema de expresión	Mammalian cells
Objetivo	CD32, CDw32, FCG2, FCGR2B, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, IGFR2, IgG Fc receptor II-b, Low affinity immunoglobulin gamma Fc region receptor II-b, CD32, CDw32, FCG2, FCGR2C, Fc-gamma RII-c, Fc-gamma-RIIc, FcRII-c, IGFR2, IgG Fc receptor II-c, Low affinity immunoglobulin gamma Fc region receptor II-c
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P31994, P31995
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	SM201
Fondo	Low affinity immunoglobulin gamma Fc region receptor II-b (CD32b/FCGR2B) is a ~34 kDa protein. Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis.
Referencias	1. Rieth N, et al. Characterization of SM201, an anti-hFcγRIIB antibody not interfering with ligand binding that mediates immune complex dependent inhibition of B cells. Immunol Lett. 2014;160(2):145-150. [HB103066]
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Imágenes

Bioactivity

Detects CD32b/FCGR2B in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD32b/FCGR2B (SM201).

Referencias

Datasheet

Anti-Human Fc gamma RIIB/CD32b Reference Antibody (SM201, RUO).pdf

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Formula

Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)

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Working Solution

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Proteínas Recombinantes

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