Anti-Human Fc gamma RIIB/CD32b Reference Antibody (SM201, RUO) (HB103066)

Name: Anti-Human Fc gamma RIIB/CD32b Reference Antibody (SM201, RUO)
Brand: abinScience
SKU: HB103066
Price: 176 USD
Availability: InStock

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SDS

Aperçu

Numéro de catalogue	HB103066
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG1
ID de clone	SM201
Activité biologique	SM201 (5 ug/mL) specifically binds to Fc-RIIB on Raji cells and shows no cross-reactivity with Fc-RIIA on K-562 cells [1]. SM201 (0.01-10 ug/mL; 1 h) does not interfere with the binding of IgG to Fc-RIIB on Raji cells [1].
Système d'expression	Mammalian cells
Cible	CD32, CDw32, FCG2, FCGR2B, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, IGFR2, IgG Fc receptor II-b, Low affinity immunoglobulin gamma Fc region receptor II-b, CD32, CDw32, FCG2, FCGR2C, Fc-gamma RII-c, Fc-gamma-RIIc, FcRII-c, IGFR2, IgG Fc receptor II-c, Low affinity immunoglobulin gamma Fc region receptor II-c
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P31994, P31995
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	SM201
Contexte	Low affinity immunoglobulin gamma Fc region receptor II-b (CD32b/FCGR2B) is a ~34 kDa protein. Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis.
Reférences	1. Rieth N, et al. Characterization of SM201, an anti-hFcγRIIB antibody not interfering with ligand binding that mediates immune complex dependent inhibition of B cells. Immunol Lett. 2014;160(2):145-150. [HB103066]
Note	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

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Bioactivity

Detects CD32b/FCGR2B in indirect ELISAs.
SDS-PAGE

SDS-PAGE for Research Grade Anti-Human CD32b/FCGR2B (SM201).

Reférences

Fiche technique

Anti-Human Fc gamma RIIB/CD32b Reference Antibody (SM201, RUO).pdf

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