中文
English
한국어
日本語
Español
Français
Русский
| カタログ番号 | HB103066 |
|---|---|
| 種反応性 | Human |
| アプリケーション | ELISA, Bioactivity: FACS, Functional assay, Research in vivo |
| 宿主種 | Human |
| クローン性 | Monoclonal |
| アイソタイプ | IgG1 |
| クローンID | SM201 |
| 生物学的活性 | SM201 (5 ug/mL) specifically binds to Fc-RIIB on Raji cells and shows no cross-reactivity with Fc-RIIA on K-562 cells [1]. SM201 (0.01-10 ug/mL; 1 h) does not interfere with the binding of IgG to Fc-RIIB on Raji cells [1]. |
| 発現システム | Mammalian cells |
| ターゲット | CD32, CDw32, FCG2, FCGR2B, Fc-gamma RII-b, Fc-gamma-RIIb, FcRII-b, IGFR2, IgG Fc receptor II-b, Low affinity immunoglobulin gamma Fc region receptor II-b, CD32, CDw32, FCG2, FCGR2C, Fc-gamma RII-c, Fc-gamma-RIIc, FcRII-c, IGFR2, IgG Fc receptor II-c, Low affinity immunoglobulin gamma Fc region receptor II-c |
| エンドトキシンレベル | < 10 EU/mg |
| 純度 | >95% purity as determined by SDS-PAGE. |
| 精製 | Protein A/G purified from cell culture supernatant. |
| アクセッション番号 | P31994, P31995 |
| 形態 | Liquid |
| 保存バッファー | 0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。 |
| 安定性と保存 | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| 別名 | SM201 |
| 背景 | Low affinity immunoglobulin gamma Fc region receptor II-b (CD32b/FCGR2B) is a ~34 kDa protein. Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. |
| 参考文献 | 1. Rieth N, et al. Characterization of SM201, an anti-hFcγRIIB antibody not interfering with ligand binding that mediates immune complex dependent inhibition of B cells. Immunol Lett. 2014;160(2):145-150. [HB103066] |
| 注意事項 | For research use only. Not suitable for clinical or therapeutic use. |
| Isotype Control | Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507) |
Detects CD32b/FCGR2B in indirect ELISAs.
SDS-PAGE for Research Grade Anti-Human CD32b/FCGR2B (SM201).
+86-027-65523339
中国武漢市深敦寺路666号C棟、武漢、430206
