

| Каталожный номер | HV029066 |
|---|---|
| Реактивность видов | Human |
| Применения | ELISA, Bioactivity: FCM, Functional assay, Research in vivo |
| Хозяинский вид | Human |
| Клоональность | Monoclonal |
| Изотип | IgG |
| ID клона | TQB2618 |
| Цель | CD366, HAVCR2, HAVcr-2, Hepatitis A virus cellular receptor 2, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIM-3, TIM3, TIMD-3, TIMD3 |
| Уровень эндотоксинов | < 10 EU/mg |
| Чистота | >95% as determined by SDS-PAGE. |
| Очистка | Protein A/G purified from cell culture supernatant. |
| Номер доступа | Q8TDQ0 |
| Форма | Liquid |
| Буфер хранения | 0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии. |
| Устойчивость и хранение | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Альтернативные названия | TQB2618 |
| Фон | Hepatitis A virus cellular receptor 2 (CD366/TIM-3) is a ~33 kDa protein. Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. 1. Gorman, JV. et al. (2014) Immunologic research 59, 56-65. PMID: 24825777 2. Monney, L. et al. (2002) Nature 415, 536-41. PMID: 11823861 3. Sánchez-Fueyo, A. et al. (2003) Nature immunology 4, 1093-101. PMID: 14556005 4. Clayton, KL. et al. (2014) Journal of immunology (Baltimore, Md. : 1950) 192, 782-91. PMID: 24337741 5. Tomkowicz, B. et al. (2015) PloS one 10, e0140694. PMID: 26492563 6. Gautron, AS. et al. (2014) European journal of immunology 44, 2703-2711. PMID: 24838857 7. Zhu, C. et al. (2005) Nature immunology 6, 1245-52. PMID: 16286920 8. Leitner, J. et al. (2013) PLoS pathogens 9, e1003253. PMID: 23555261 9. Gleason, MK. et al. (2012) Blood 119, 3064-72. PMID: 22323453 |
| Ссылки | 1. Wu L, et al. MA11. 12 A Phase Ib Study of TQB2618 (Anti-TIM-3) in Combination with Penpulimab and Chemotherapy in Patients with Non-Small Cell Lung Cancer[J]. Journal of Thoracic Oncology, 2024, 19(10): S100. [HV029066] |
| Примечание | For research use only. Not suitable for clinical or therapeutic use. |

SDS-PAGE for Research Grade Anti-Human CD366/HAVCR2/TIM-3 (TQB2618)




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