Anti-Human CD27 Ligand/TNFSF7/CD70 Reference Antibody (BMS936561, RUO) (HW717046)

Name: Anti-Human CD27 Ligand/TNFSF7/CD70 Reference Antibody (BMS936561, RUO)
Brand: abinScience
SKU: HW717046
Price: 370 USD
Availability: InStock

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100ug
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Aperçu
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Reférences
Fiche technique
SDS

Aperçu

Numéro de catalogue

HW717046

Reactivité des espèces

Human

Applications

ELISA, Bioactivity: FACS, Functional assay, Research in vivo

Espèce hôte

Human

Clonalité

Monoclonal

Isotype

IgG

ID de clone

BMS936561

Activité biologique

CD70 (TNFSF7) is a type II transmembrane glycoprotein belonging to the tumor necrosis factor superfamily and serves as the specific ligand for CD27. It mediates T and B cell activation, proliferation, and immune regulation; notably, it is aberrantly overexpressed in various tumors, making it a highly promising target for cancer immunotherapy.

Système d'expression

Mammalian cells

Cible

CD27 ligand, CD70, TNFSF7, CD27LG, CD27L, CD70 antigen, Tumor necrosis factor ligand superfamily member 7, CD27-L

Niveau d'endotoxines

< 10 EU/mg

Pureté

>95% purity as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Numéro d'accès

P32970

Forme

Liquid

Tampon de stockage

0.01M PBS pH 7.4

Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.

Informations d'utilisation du produit

Application	Dilution
ELISA	1:2000-1:20000

Stabilité et stockage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Noms alternatifs

BMS936561, MDX-1115, MDX-1203

Contexte

CD70 antigen is a ~21 kDa protein. Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells. The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells.

1. Izawa, K. et al. (2017) The Journal of experimental medicine 214, 73-89. PMID: 28011863

2. Abolhassani, H. et al. (2017) The Journal of experimental medicine 214, 91-106. PMID: 28011864

3. Goodwin, RG. et al. (1993) Cell 73, 447-56. PMID: 8387892

Reférences

1. Owonikoko TK, et al. First-in-human multicenter phase I study of BMS-936561 (MDX-1203), an antibody-drug conjugate targeting CD70. Cancer Chemother Pharmacol. 2016 Jan;77(1):155-62. [HW717046]

Note

For research use only. Not suitable for clinical or therapeutic use.

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