Anti-Human CD27 Ligand/TNFSF7/CD70 Reference Antibody (MDX-1411, RUO) (HW717056)

Name: Anti-Human CD27 Ligand/TNFSF7/CD70 Reference Antibody (MDX-1411, RUO)
Brand: abinScience
SKU: HW717056
Price: 370 USD
Availability: InStock

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Número de catálogo	HW717056
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	MDX-1411
Sistema de expresión	Mammalian cells
Objetivo	CD27 ligand, CD70, TNFSF7, CD27LG, CD27L, CD70 antigen, Tumor necrosis factor ligand superfamily member 7, CD27-L
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P32970
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	MDX-1411, MDX1411, MDX1411
Fondo	CD70 antigen is a ~21 kDa protein. Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells. The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells. 1. Izawa, K. et al. (2017) The Journal of experimental medicine 214, 73-89. PMID: 28011863 2. Abolhassani, H. et al. (2017) The Journal of experimental medicine 214, 91-106. PMID: 28011864 3. Goodwin, RG. et al. (1993) Cell 73, 447-56. PMID: 8387892
Referencias	1. Quintás-Cardama A, et al. Investigational immunotherapeutics for B-cell malignancies. J Clin Oncol. 2010 Feb 10;28(5):884-92. [HW717056]
Nota	For research use only. Not suitable for clinical or therapeutic use.