Protein A/G purified from cell culture supernatant.
Número de acceso
P21589
Forma
Liquid
Buffer de almacenamiento
0.01M PBS pH 7.4.
Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos
BMS-986179, BMS986179, BMS986179
Fondo
5'-nucleotidase (CD73/NT5E) is a ~63 kDa protein. Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate. Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms. Other substrates include IMP, UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD and NMN.
1. Garavaglia, S. et al. (2012) The Biochemical journal 441, 131-41. PMID: 21933152
2. Heuts, DP. et al. (2012) Chembiochem : a European journal of chemical biology 13, 2384-91. PMID: 22997138
3. Knapp, K. et al. (2012) Structure (London, England : 1993) 20, 2161-73. PMID: 23142347
4. Fausther, M. et al. (2014) PloS one 9, e98568. PMID: 24887587
5. Scaletti, E. et al. (2021) Purinergic signalling 17, 693-704. PMID: 34403084
Referencias
1. Siu L L, et al. Abstract CT180: Preliminary phase 1 profile of BMS-986179, an anti-CD73 antibody, in combination with nivolumab in patients with advanced solid tumors[J]. Cancer Research, 2018, 78(13_Supplement): CT180-CT180. [HB209096]
Nota
For research use only. Not suitable for clinical or therapeutic use.
Imágenes
SDS-PAGE
SDS-PAGE for Research Grade Anti-Human CD73/NT5E (BMS-986179)
中文
English
한국어
日本語
Español
Français
Русский
