Protein A/G purified from cell culture supernatant.
Numéro d'accès
P21589
Forme
Liquid
Tampon de stockage
0.01M PBS pH 7.4.
Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs
BMS-986179, BMS986179, BMS986179
Contexte
5'-nucleotidase (CD73/NT5E) is a ~63 kDa protein. Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate. Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms. Other substrates include IMP, UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD and NMN.
1. Garavaglia, S. et al. (2012) The Biochemical journal 441, 131-41. PMID: 21933152
2. Heuts, DP. et al. (2012) Chembiochem : a European journal of chemical biology 13, 2384-91. PMID: 22997138
3. Knapp, K. et al. (2012) Structure (London, England : 1993) 20, 2161-73. PMID: 23142347
4. Fausther, M. et al. (2014) PloS one 9, e98568. PMID: 24887587
5. Scaletti, E. et al. (2021) Purinergic signalling 17, 693-704. PMID: 34403084
Reférences
1. Siu L L, et al. Abstract CT180: Preliminary phase 1 profile of BMS-986179, an anti-CD73 antibody, in combination with nivolumab in patients with advanced solid tumors[J]. Cancer Research, 2018, 78(13_Supplement): CT180-CT180. [HB209096]
Note
For research use only. Not suitable for clinical or therapeutic use.
Images
SDS-PAGE
SDS-PAGE for Research Grade Anti-Human CD73/NT5E (BMS-986179)
中文
English
한국어
日本語
Español
Français
Русский
