Anti-Human Cannabinoid R1/CB1/CNR1 Reference Antibody (GFB-024, RUO) (HB822026)

Name: Anti-Human Cannabinoid R1/CB1/CNR1 Reference Antibody (GFB-024, RUO)
Brand: abinScience
SKU: HB822026
Price: 370 USD
Availability: InStock

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概要

カタログ番号	HB822026
説明	Anti-Human CNR1/CB1 (GFB-024) (HB822026) is a research-grade recombinant antibody targeting CNR1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG
クローンID	GFB-024
発現システム	Mammalian cells
ターゲット	CNR1, CB1, CANN6, CB-R, CNR, Cannabinoid receptor 1
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	P21554
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	GFB-024, GFB024, GFB024
背景	Cannabinoid receptor 1 (CNR1/CB1) is a ~52 kDa protein. G-protein coupled receptor for endogenous cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG), as well as phytocannabinoids, such as delta(9)-tetrahydrocannabinol (THC). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while decreases respiration at high doses. 1. Ryberg, E. et al. (2005) FEBS letters 579, 259-64. PMID: 15620723 2. Hua, T. et al. (2016) Cell 167, 750-762.e14. PMID: 27768894 3. Shao, Z. et al. (2016) Nature 540, 602-606. PMID: 27851727 4. Yang, X. et al. (2022) Nature chemical biology 18, 831-840. PMID: 35637350 5. Gérard, CM. et al. (1991) The Biochemical journal 279 ( Pt 1), 129-34. PMID: 1718258 6. Oddi, S. et al. (2012) British journal of pharmacology 165, 2635-51. PMID: 21895628 7. Niehaus, JL. et al. (2007) Molecular pharmacology 72, 1557-66. PMID: 17895407 8. Jourdan, T. et al. (2013) Nature medicine 19, 1132-40. PMID: 23955712
注意事項	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human CNR1/CB1 (GFB-024)

参考文献

データシート

Anti-Human Cannabinoid R1/CB1/CNR1 Reference Antibody (GFB-024, RUO).pdf

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Anti-Human Cannabinoid R1/CB1/CNR1 Reference Antibody (GFB-024, RUO) (HB822026)

概要

イメージ

参考文献

データシート

SDS

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