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Anti-Human Complement C2 Reference Antibody (ARGX-117, RUO) (HY106026)

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Anti-Human Complement C2 Reference Antibody (ARGX-117, RUO)
Anti-Human Complement C2 Reference Antibody (ARGX-117, RUO)
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Vista general
Número de catálogoHY106026
Descripción
Anti-Human Complement C2 Antibody (ARGX-117) (HY106026) is a research-grade recombinant antibody targeting Complement C2. Produced in mammalian cells with native-like glycosylation.
Highlights
  • ●Research Grade — For PK/PD studies, assay development, and ADA research.
  • ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especiesHuman
AplicacionesELISA, Bioactivity: FCM, Functional assay, Research in vivo
Especie huéspedHuman
ClonalidadMonoclonal
IsotipoIgG
ID de clonARGX-117
Sistema de expresión Mammalian cells
Naturaleza Recombinant
Objetivo Complement C2, C2, C3/C5 convertase
Nivel de endotoxinas < 10 EU/mg as determined by LAL method.
Pureza >95% as determined by SDS-PAGE.
Purificación Protein A/G purified from cell culture supernatant.
Número de acceso P06681
Forma Liquid
Buffer de almacenamiento 0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativosARGX-117, ARGX117, ARGX117
Fondo

Complement C2 is a ~83 kDa protein. Precursor of the catalytic component of the C3 and C5 convertase complexes, which are part of the complement pathway, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Component C2 is part of the classical, lectin and GZMK complement systems.

1. Rawal, N. et al. (2003) The Journal of biological chemistry 278, 38476-83. PMID: 12878586
2. Milder, FJ. et al. (2006) Structure (London, England : 1993) 14, 1587-97. PMID: 17027507
3. Rawal, N. et al. (2008) The Journal of biological chemistry 283, 7853-63. PMID: 18204047
4. Donado, CA. et al. (2025) Nature 641, 211-221. PMID: 39914456
5. Lan, F. et al. (2025) Nature 638, 490-498. PMID: 39814882
6. Héja, D. et al. (2012) Proceedings of the National Academy of Sciences of the United States of America 109, 10498-503. PMID: 22691502
Nota For research use only. Not suitable for clinical or therapeutic use.
Imágenes
  • Anti-Human Complement C2 Reference Antibody (ARGX-117, RUO)

    SDS-PAGE

    SDS-PAGE for Research Grade Anti-Human Complement C2 Antibody (ARGX-117)

Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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