Anti-Human CXCL10/IP-10 Reference Antibody (NI-0801, RUO) (HY524026)

Name: Anti-Human CXCL10/IP-10 Reference Antibody (NI-0801, RUO)
Brand: abinScience
SKU: HY524026
Price: 370 USD
Availability: InStock

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Numéro de catalogue	HY524026
Description	Anti-Human CXCL10/IP-10 (NI-0801) (HY524026) is a research-grade recombinant antibody targeting Gamma-IP10. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG
ID de clone	NI-0801
Système d'expression	Mammalian cells
Nature	Recombinant
Cible	Gamma-IP10, C-X-C motif chemokine 10, INP10, 10 kDa interferon gamma-induced protein, Small-inducible cytokine B10, SCYB10, IP-10, CXCL10
Niveau d'endotoxines	< 10 EU/mg as determined by LAL method.
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P02778
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	NI-0801, NI0801, NI0801
Contexte	C-X-C motif chemokine 10 (CXCL10/IP-10) is a ~10 kDa protein. Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. 1. Romagnani, P. et al. (2001) Blood 97, 601-7. PMID: 11157474 2. Sidahmed, AM. et al. (2012) Cytokine 59, 433-41. PMID: 22652417 3. Angiolillo, AL. et al. (1995) The Journal of experimental medicine 182, 155-62. PMID: 7540647 4. Smit, MJ. et al. (2003) Blood 102, 1959-65. PMID: 12750173 5. Gao, JM. et al. (2009) Acta pharmacologica Sinica 30, 193-201. PMID: 19151743 6. Cheeran, MC. et al. (2003) Journal of virology 77, 4502-15. PMID: 12663757
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human CXCL10/IP-10 (NI-0801)

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Anti-Human CXCL10/IP-10 Reference Antibody (NI-0801, RUO).pdf

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Anti-Human CXCL10/IP-10 Reference Antibody (NI-0801, RUO) (HY524026)

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