Anti-Human DAG1/Dystroglycan Reference Antibody (DAG-6F4, RUO) (HC564016)

Name: Anti-Human DAG1/Dystroglycan Reference Antibody (DAG-6F4, RUO)
Brand: abinScience
SKU: HC564016
Price: 370 USD
Availability: InStock

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Numéro de catalogue	HC564016
Description	Anti-Human DAG1/Dystroglycan (DAG-6F4) (HC564016) is a research-grade recombinant antibody targeting Dystrophin-associated glycoprotein 1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG
ID de clone	DAG-6F4
Système d'expression	Mammalian cells
Nature	Recombinant
Cible	Dystrophin-associated glycoprotein 1, DAG1, Alpha-DG, Dystroglycan, Beta-DG
Niveau d'endotoxines	< 10 EU/mg as determined by LAL method.
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q14118
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	DAG-6F4, DAG6F4, DAG6F4
Contexte	Dystroglycan 1 (DAG1) is a ~97 kDa protein. The dystroglycan complex is involved in a number of signaling events and processes including laminin deposition and extracellular matrix assembly, acetylcholine receptor clustering, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, epithelial polarization, and epithelium branching morphogenesis. Required for the formation of photoreceptor ribbon synapses, and long-term maintenance of inhibitory synapses in cerebellar Purkinje cells. Also involved in the positive regulation of cartilage formation through agrin (AGRN) binding and up-regulation of SOX9, a transcription factor that plays a key role in chondrocytes differentiation. 1. Eldridge, S. et al. (2016) Annals of the rheumatic diseases 75, 1228-35. PMID: 26290588
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human DAG1/Dystroglycan (DAG-6F4)

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Anti-Human DAG1/Dystroglycan Reference Antibody (DAG-6F4, RUO).pdf

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Anti-Human DAG1/Dystroglycan Reference Antibody (DAG-6F4, RUO) (HC564016)

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