Anti-Human GP88/GRN Reference Antibody (AG1, RUO) (HB264016)

Name: Anti-Human GP88/GRN Reference Antibody (AG1, RUO)
Brand: abinScience
SKU: HB264016
Price: 176 USD
Availability: InStock

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Обзор

Каталожный номер	HB264016
Описание	Anti-Human GP88/GRN (AG1) (HB264016) is a research-grade recombinant antibody targeting PC cell-derived growth factor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG
ID клона	AG1
Система экспрессии	Mammalian cells
Цель	PC cell-derived growth factor, Granulin G, Epithelin precursor, Epithelin-1, Granulin A, Acrogranin, Progranulin, Granulin F, Proepithelin, PGRN, Glycoprotein of 88 Kda, GRN, Granulin C, Granulin E, Granulin precursor, PEPI, PCDGF, Granulin D, Glycoprotein 88, Epithelin-2, GP88, Granulin B
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P28799
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	AG1
Фон	Progranulin (GP88/GRN) is a ~63 kDa protein. Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes. Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases. 1. Zhu, J. et al. (2002) Cell 111, 867-78. PMID: 12526812 2. Van Damme, P. et al. (2008) The Journal of cell biology 181, 37-41. PMID: 18378771 3. Tanaka, Y. et al. (2017) Human molecular genetics 26, 969-988. PMID: 28073925 4. Beel, S. et al. (2017) Human molecular genetics 26, 2850-2863. PMID: 28453791 5. Zhou, X. et al. (2017) Nature communications 8, 15277. PMID: 28541286
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Изображения

SDS-PAGE

SDS-PAGE for Research Grade Anti-Human GP88/GRN (AG1)

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Даташит

Anti-Human GP88/GRN Reference Antibody (AG1, RUO).pdf

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