Anti-Human Glypican 3 Reference Antibody (CAT-07, RUO) (HW310056)

Name: Anti-Human Glypican 3 Reference Antibody (CAT-07, RUO)
Brand: abinScience
SKU: HW310056
Price: 370 USD
Availability: InStock

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Número de catálogo	HW310056
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	CAT-07
Actividad biológica	GPC3 is a cell surface heparan sulfate proteoglycan involved in cell growth and differentiation, and often studied in cancer research, particularly hepatocellular carcinoma. It is produced in mammalian cells, ensuring native-like glycosylation patterns, which is important for maintaining proper antigen recognition and functional studies.
Sistema de expresión	Mammalian cells
Objetivo	GPC3, MXR7, GTR2-2, Glypican-3, Intestinal protein OCI-5, OCI5
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	P51654
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	CAT-07, CAT07, CAT07
Fondo	Glypican-3 (GPC3/Glypican 3) is a ~65 kDa protein. Cell surface proteoglycan. Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins. Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation. Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands. Positively regulates the non-canonical Wnt signaling pathway. 1. De Cat, B. et al. (2003) The Journal of cell biology 163, 625-35. PMID: 14610063 2. Capurro, MI. et al. (2005) The Journal of biological chemistry 280, 41201-6. PMID: 16227623 3. Capurro, M. et al. (2014) Journal of cell science 127, 1565-75. PMID: 24496449 4. Davoodi, J. et al. (2007) Proteomics 7, 2300-10. PMID: 17549790
Nota	For research use only. Not suitable for clinical or therapeutic use.