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Anti-Human IL-10 Reference Antibody (SCH708980, RUO) (HB997046)

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Anti-Human IL-10 Reference Antibody (SCH708980, RUO)
Anti-Human IL-10 Reference Antibody (SCH708980, RUO)
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Vista general
Número de catálogoHB997046
Descripción
Anti-Human IL-10 Reference Antibody (SCH708980, RUO) (HB997046) is a human monoclonal antibody detecting IL-10.
Reactividad de especiesHuman
AplicacionesELISA, Bioactivity: FCM, Functional assay, Research in vivo
Especie huéspedHuman
ClonalidadMonoclonal
IsotipoIgG
ID de clonSCH708980
Sistema de expresión Mammalian cells
Naturaleza Recombinant
Objetivo CSIF, Cytokine synthesis inhibitory factor, IL-10, IL10, Interleukin-10
Nivel de endotoxinas < 10 EU/mg as determined by LAL method.
Pureza >95% as determined by SDS-PAGE.
Purificación Protein A/G purified from cell culture supernatant.
Número de acceso P22301
Forma Liquid
Buffer de almacenamiento 0.01M PBS pH 7.4.

Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativosSCH708980
Fondo

Interleukin-10 (IL10) is a ~20 kDa protein. Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF. Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation.

1. Yoon, SI. et al. (2006) The Journal of biological chemistry 281, 35088-96. PMID: 16982608
2. El Kasmi, KC. et al. (2007) Journal of immunology (Baltimore, Md. : 1950) 179, 7215-9. PMID: 18025162
3. Hashimoto, SI. et al. (2001) Journal of immunology (Baltimore, Md. : 1950) 167, 3619-25. PMID: 11564774
4. de Waal Malefyt, R. et al. (1991) The Journal of experimental medicine 174, 1209-20. PMID: 1940799
5. Willems, F. et al. (1994) European journal of immunology 24, 1007-9. PMID: 7512027
6. Frei, K. et al. (1994) Journal of immunology (Baltimore, Md. : 1950) 152, 2720-8. PMID: 8144879
Referencias 1. Wang C, et al. Text Mining and Drug Discovery Analysis: A Comprehensive Approach to Investigate Diabetes-Induced Osteoporosis. Int J Med Sci. 2024 Jan 1;21(3):464-473. [HB997046]
2. Sun S, et al. Identification of potential hub genes and drugs in septic kidney injury: a bioinformatic analysis with preliminary experimental validation. Front Med (Lausanne). 2025 Mar 17;12:1502189. [HB997046]
3. Vacchelli E, et al. Trial Watch: Immunostimulatory cytokines. Oncoimmunology. 2012 Jul 1;1(4):493-506. [HB997046]
Nota For research use only. Not suitable for clinical or therapeutic use.
Imágenes
  • Anti-Human IL-10 Reference Antibody (SCH708980, RUO)

    SDS-PAGE

    SDS-PAGE for Research Grade Anti-Human IL10 (SCH708980)

Referencias
Datasheet
Download SDS PDF
Formula
Mass (g) = Concentration (mol/L) × Volume (L) × MW (g/mol)
Enter any 2 of Mass, Concentration, Volume + Molecular Weight to solve for the unknown.
Mass
=
Concentration
×
Volume
Molecular Weight *
g/mol
Formula
C₁ × V₁ = C₂ × V₂
Enter any 3 of the 4 values to solve for the unknown.
Stock Solution
C₁ (Stock Conc.)
×
V₁ (Stock Vol.)
=
Working Solution
C₂ (Working Conc.)
×
V₂ (Working Vol.)
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