Anti-Human IL-18 Reference Antibody (GSK 1070806, RUO) (HC517046)

Name: Anti-Human IL-18 Reference Antibody (GSK 1070806, RUO)
Brand: abinScience
SKU: HC517046
Price: 370 USD
Availability: InStock

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SDS

Vista general

Número de catálogo	HC517046
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG1-kappa
ID de clon	GSK 1070806
Actividad biológica	GSK-1070806 does not improve glucose control in a type 2 diabetes mellitus study [1].
Sistema de expresión	Mammalian cells
Aplicaciones probadas	WB
Objetivo	IFN-gamma-inducing factor, IL1F4, Interleukin-1 gamma, IL-18, IL-1 gamma, Interleukin-18, Interferon gamma-inducing factor, IGIF, IL18, Iboctadekin
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q14116
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	GSK-1070806, GSK1070806, GSK1070806
Fondo	Interleukin-18 (IL18/IL1F4) is a ~22 kDa protein. Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. 1. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850 2. Kato, Z. et al. (2003) Nature structural biology 10, 966-71. PMID: 14528293 3. Tsutsumi, N. et al. (2014) Nature communications 5, 5340. PMID: 25500532 4. Shi, X. et al. (2023) Nature 624, 442-450. PMID: 37993714 5. Xia, S. et al. (2021) Nature 593, 607-611. PMID: 33883744
Referencias	1. Fenini G, Contassot E, French L E. Potential of IL-1, IL-18 and inflammasome inhibition for the treatment of inflammatory skin diseases[J]. Frontiers in pharmacology, 2017, 8: 278. [HC517046]
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Imágenes

Western blot

Western blot analysis was performed using anti-human IL18 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human IL18 (Catalog No: HC517012)
Lane 2: negative control
Bioactivity

Detects recombinant human IL18/IL1F4 (Catalog No: HC517012) in indirect ELISA