Anti-Human IL-18 Reference Antibody (GSK 1070806, RUO) (HC517046)

Name: Anti-Human IL-18 Reference Antibody (GSK 1070806, RUO)
Brand: abinScience
SKU: HC517046
Price: 370 USD
Availability: InStock

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100ug
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5mg
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概要
イメージ
参考文献
データシート
SDS

概要

カタログ番号	HC517046
種反応性	Human
アプリケーション	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
宿主種	Human
クローン性	Monoclonal
アイソタイプ	IgG1-kappa
クローンID	GSK 1070806
生物学的活性	GSK-1070806 does not improve glucose control in a type 2 diabetes mellitus study [1].
発現システム	Mammalian cells
テスト済みアプリケーション	WB
ターゲット	IFN-gamma-inducing factor, IL1F4, Interleukin-1 gamma, IL-18, IL-1 gamma, Interleukin-18, Interferon gamma-inducing factor, IGIF, IL18, Iboctadekin
エンドトキシンレベル	< 10 EU/mg
純度	>95% purity as determined by SDS-PAGE.
精製	Protein A/G purified from cell culture supernatant.
アクセッション番号	Q14116
形態	Liquid
保存バッファー	0.01M PBS pH 7.4 データシートのハードコピーまたはロット固有のCOAに記載された具体的なバッファー情報を参照してください。
安定性と保存	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
別名	GSK-1070806, GSK1070806, GSK1070806
背景	Interleukin-18 (IL18/IL1F4) is a ~22 kDa protein. Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore. 1. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850 2. Kato, Z. et al. (2003) Nature structural biology 10, 966-71. PMID: 14528293 3. Tsutsumi, N. et al. (2014) Nature communications 5, 5340. PMID: 25500532 4. Shi, X. et al. (2023) Nature 624, 442-450. PMID: 37993714 5. Xia, S. et al. (2021) Nature 593, 607-611. PMID: 33883744
参考文献	1. Fenini G, Contassot E, French L E. Potential of IL-1, IL-18 and inflammasome inhibition for the treatment of inflammatory skin diseases[J]. Frontiers in pharmacology, 2017, 8: 278. [HC517046]
注意事項	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

イメージ

Western blot

Western blot analysis was performed using anti-human IL18 monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human IL18 (Catalog No: HC517012)
Lane 2: negative control
Bioactivity

Detects recombinant human IL18/IL1F4 (Catalog No: HC517012) in indirect ELISA