Anti-Human IL-1 alpha/IL-1F1 Reference Antibody (XB2001, RUO) (HF802046)

Name: Anti-Human IL-1 alpha/IL-1F1 Reference Antibody (XB2001, RUO)
Brand: abinScience
SKU: HF802046
Price: 370 USD
Availability: InStock

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Numéro de catalogue	HF802046
Description	Anti-Human IL1A/IL1F1 (XB2001) (HF802046) is a research-grade recombinant antibody targeting IL1F1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG
ID de clone	XB2001
Système d'expression	Mammalian cells
Nature	Recombinant
Cible	IL1F1, Interleukin-1 alpha, IL1A, Hematopoietin-1, IL-1 alpha
Niveau d'endotoxines	< 10 EU/mg as determined by LAL method.
Pureté	>95% as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	P01583
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4. Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	XB2001
Contexte	Interleukin-1 alpha (IL1A/IL1F1) is a ~30 kDa protein. Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. 1. Cohen, I. et al. (2015) Scientific reports 5, 14756. PMID: 26439902 2. Brikos, C. et al. (2007) Molecular & cellular proteomics : MCP 6, 1551-9. PMID: 17507369 3. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091 4. Wu, T. et al. (2004) Cytokine 25, 11-20. PMID: 14687581 5. Spiekstra, SW. et al. (2005) Experimental dermatology 14, 109-16. PMID: 15679580
Note	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human IL1A/IL1F1 (XB2001)

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Anti-Human IL-1 alpha/IL-1F1 Reference Antibody (XB2001, RUO).pdf

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Anti-Human IL-1 alpha/IL-1F1 Reference Antibody (XB2001, RUO) (HF802046)

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