Anti-Human IL-1 alpha/IL-1F1 Reference Antibody (XB2001, RUO) (HF802046)

Name: Anti-Human IL-1 alpha/IL-1F1 Reference Antibody (XB2001, RUO)
Brand: abinScience
SKU: HF802046
Price: 370 USD
Availability: InStock

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100ug
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Каталожный номер	HF802046
Описание	Anti-Human IL1A/IL1F1 (XB2001) (HF802046) is a research-grade recombinant antibody targeting IL1F1. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Реактивность видов	Human
Применения	ELISA, Bioactivity: FCM, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG
ID клона	XB2001
Система экспрессии	Mammalian cells
Характер	Recombinant
Цель	IL1F1, Interleukin-1 alpha, IL1A, Hematopoietin-1, IL-1 alpha
Уровень эндотоксинов	< 10 EU/mg as determined by LAL method.
Чистота	>95% as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P01583
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4. Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	XB2001
Фон	Interleukin-1 alpha (IL1A/IL1F1) is a ~30 kDa protein. Cytokine constitutively present intracellularly in nearly all resting non-hematopoietic cells that plays an important role in inflammation and bridges the innate and adaptive immune systems. After binding to its receptor IL1R1 together with its accessory protein IL1RAP, forms the high affinity interleukin-1 receptor complex. Signaling involves the recruitment of adapter molecules such as MYD88, IRAK1 or IRAK4. In turn, mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways. Within the cell, acts as an alarmin and cell death results in its liberation in the extracellular space after disruption of the cell membrane to induce inflammation and alert the host to injury or damage. 1. Cohen, I. et al. (2015) Scientific reports 5, 14756. PMID: 26439902 2. Brikos, C. et al. (2007) Molecular & cellular proteomics : MCP 6, 1551-9. PMID: 17507369 3. Mosley, B. et al. (1987) The Journal of biological chemistry 262, 2941-4. PMID: 2950091 4. Wu, T. et al. (2004) Cytokine 25, 11-20. PMID: 14687581 5. Spiekstra, SW. et al. (2005) Experimental dermatology 14, 109-16. PMID: 15679580
Примечание	For research use only. Not suitable for clinical or therapeutic use.

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SDS-PAGE for Research Grade Anti-Human IL1A/IL1F1 (XB2001)

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Anti-Human IL-1 alpha/IL-1F1 Reference Antibody (XB2001, RUO).pdf

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Anti-Human IL-1 alpha/IL-1F1 Reference Antibody (XB2001, RUO) (HF802046)

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