Anti-Human IL-1 beta/IL-1F2 Reference Antibody (LY2189102, RUO) (HF943076)

Name: Anti-Human IL-1 beta/IL-1F2 Reference Antibody (LY2189102, RUO)
Brand: abinScience
SKU: HF943076
Price: 370 USD
Availability: InStock

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100ug
1mg
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25mg
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Обзор
Изображения
Ссылки
Даташит
SDS

Обзор

Каталожный номер	HF943076
Реактивность видов	Human
Применения	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Хозяинский вид	Human
Клоональность	Monoclonal
Изотип	IgG
ID клона	LY2189102
Система экспрессии	Mammalian cells
Проверенные приложения	WB
Цель	Interleukin-1 beta, IL1B, Catabolin, IL1F2, IL-1 beta
Уровень эндотоксинов	< 10 EU/mg
Чистота	>95% purity as determined by SDS-PAGE.
Очистка	Protein A/G purified from cell culture supernatant.
Номер доступа	P01584
Форма	Liquid
Буфер хранения	0.01M PBS pH 7.4 Пожалуйста, обратитесь к конкретной информации о буфере в печатной версии даташита или в индивидуальном сертификате качества (COA) для партии.
Устойчивость и хранение	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Альтернативные названия	LY2189102
Фон	Interleukin-1 beta (IL1B/IL1F2) is a ~30 kDa protein. Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. IL1B is the therapeutic target of canakinumab (Ilaris). 1. Tominaga, K. et al. (2000) International immunology 12, 151-60. PMID: 10653850 2. Nakahara, H. et al. (2003) Arthritis and rheumatism 48, 1521-9. PMID: 12794819 3. LaRock, CN. et al. (2016) Science immunology 1. PMID: 28331908 4. Van Damme, J. et al. (1985) Nature 314, 266-8. PMID: 3920526 5. Tian, XX. et al. (2021) International endodontic journal 54, 916-925. PMID: 33377178 6. Xia, S. et al. (2021) Nature 593, 607-611. PMID: 33883744
Ссылки	1. Sloan-Lancaster J, et al. Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL-1β antibody, in patients with type 2 diabetes. Diabetes Care. 2013 Aug;36(8):2239-46. [HF943076]
Примечание	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Изображения

Western blot

Western blot analysis was performed using anti-human IL1B monoclonal antibody at 1ug/mL on various samples.
Lane 1: recombinant human IL1B (Catalog No: HF943012)
Lane 2: negative control
Bioactivity

Detects recombinant human IL1B/IL1F2 (Catalog No: HF943012) in indirect ELISA