Anti-Human Ly-6A/E Reference Antibody (RG 7841, RUO) (HS714016)

Name: Anti-Human Ly-6A/E Reference Antibody (RG 7841, RUO)
Brand: abinScience
SKU: HS714016
Price: 176 USD
Availability: InStock

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Número de catálogo	HS714016
Descripción	Anti-Human LY6E/SCA-2 (RG 7841) (HS714016) is a research-grade recombinant antibody targeting SCA-2. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactividad de especies	Human
Aplicaciones	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Especie huésped	Human
Clonalidad	Monoclonal
Isotipo	IgG
ID de clon	RG 7841
Sistema de expresión	Mammalian cells
Objetivo	SCA-2, TSA-1, 9804, Retinoic acid-induced gene E protein, TSA1, Lymphocyte antigen 6E, Ly-6E, Stem cell antigen 2, Thymic shared antigen 1, SCA2, RIGE, LY6E, RIG-E
Nivel de endotoxinas	< 10 EU/mg
Pureza	>95% purity as determined by SDS-PAGE.
Purificación	Protein A/G purified from cell culture supernatant.
Número de acceso	Q16553
Forma	Liquid
Buffer de almacenamiento	0.01M PBS pH 7.4 Consulte la información específica del buffer en la copia impresa del datasheet o en el COA específico del lote.
Estabilidad y almacenamiento	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Nombres alternativos	RG-7841, RG7841, RG7841
Fondo	Lymphocyte antigen 6E (LY6E/SCA-2) is a ~13 kDa protein. GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. 1. Zhao, X. et al. (2020) Journal of virology 94. PMID: 32641482
Nota	For research use only. Not suitable for clinical or therapeutic use.
Isotype Control	Human IgG1 Recombinant Isotype Control Antibody (13R4) (HV080507)

Imágenes

Bioactivity

SEC-HPLC detection for Research Grade Anti-Human LY6E/SCA-2 (RG 7841).
SDS-PAGE

SDS-PAGE for Research Grade Anti-Human LY6E/SCA-2 (RG 7841).