Anti-Human NRG1/Neuregulin-1 Reference Antibody (JK07, RUO) (HX096016)

Name: Anti-Human NRG1/Neuregulin-1 Reference Antibody (JK07, RUO)
Brand: abinScience
SKU: HX096016
Price: 370 USD
Availability: InStock

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Numéro de catalogue	HX096016
Description	Anti-Human NRG1/Neuregulin-1 (JK07) (HX096016) is a research-grade recombinant antibody targeting Glial growth factor. Produced in mammalian cells with native-like glycosylation. Highlights ●Research Grade — For PK/PD studies, assay development, and ADA research. ●Native Glycosylation — Mammalian expression ensures native-like patterns.
Reactivité des espèces	Human
Applications	ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Espèce hôte	Human
Clonalité	Monoclonal
Isotype	IgG
ID de clone	JK07
Système d'expression	Mammalian cells
Cible	Glial growth factor, Neu differentiation factor, SMDF, Breast cancer cell differentiation factor p45, Pro-neuregulin-1, membrane-bound isoform, Acetylcholine receptor-inducing activity, ARIA, GGF, HRGA, Pro-NRG1, HGL, HRG, NDF, NRG1, Sensory and motor neuron-derived factor, Heregulin
Niveau d'endotoxines	< 10 EU/mg
Pureté	>95% purity as determined by SDS-PAGE.
Purification	Protein A/G purified from cell culture supernatant.
Numéro d'accès	Q02297
Forme	Liquid
Tampon de stockage	0.01M PBS pH 7.4 Reférez-vous aux informations spécifiques sur le tampon dans la copie papier du datasheet ou dans le COA spécifique au lot.
Stabilité et stockage	Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Noms alternatifs	JK07
Contexte	Pro-neuregulin-1, membrane-bound isoform (NRG1) is a ~70 kDa protein. Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4. 1. Sweeney, C. et al. (2000) The Journal of biological chemistry 275, 19803-7. PMID: 10867024 2. Plowman, GD. et al. (1993) Nature 366, 473-5. PMID: 7902537 3. Ieguchi, K. et al. (2010) The Journal of biological chemistry 285, 31388-98. PMID: 20682778
Note	For research use only. Not suitable for clinical or therapeutic use.